Browse active challenges from the government | USAGov

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See select challenges and prize competitions that are active now. Learn where you can get more information on each challenge.

2026 NASA Revolutionary Aerospace Systems Concepts – Academic Linkage (RASC-AL) Competition

Develop new ideas that could help people explore and work on the Moon, Mars, and beyond. U.S.-based college students: learn more and apply.
Beauty + Health: Youth Graphic Medicine Challenge

Create comics to help reduce health risks and pressure to meet society’s beauty standards.
NASA’s 2026 Human Lander Challenge

Help shape the future of human spaceflight. U.S.-based college students: learn more and apply.
NIH Complement Animal Research in Experimentation NAMs Reduction to Practice Challenge

Develop human-based new approach methodologies (NAMs) – including lab-based human cell systems, computer models, and biochemical assays.
Oligonucleotide Toxicity (OligoTox) Open Data Challenge

Help improve in silico models for predicting toxicity using high-quality, open datasets.
Presidential 1776 Award

High school students: showcase your understanding of civics and knowledge of America’s founding.
Tactical Missile Innovation Challenge

Propose a new way to develop more affordable, adaptable, and relevant all-up-round (AUR) missiles.
Targeted Genome Editor Delivery (TARGETED) Challenge

Develop programmable delivery systems and non-viral delivery across the blood-brain barrier.

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